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In contrast, secondary metabolites are compounds that are not needed for life, usually not only possessing a wide range of biological functions but also having special mechanisms of action (Li et al., 2021)

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Because vascular relaxation is a critical process to maintain blood pressure (143), evidence indicates that arsenic exposure can contribute to hypertension (one of the key characteristics of the MS) by disrupting NO signaling and K + currents in the endothelium and vascular smooth muscle cells