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Karlenius TC, Tonissen KF (2010) Thioredoxin and cancer: a role for thioredoxin in all states of tumor oxygenation

Endogenous ROS sources (Figure 1) include the following: Mitochondrial oxidative phosphorylation: Electron leak leads to superoxide and H 2 O 2 formation

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The buildup of TDP-43 in the cytoplasm makes it easier for PS and TDP-43 to form a complex that clumps and hardens with time (127)