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Similarly, trauma induced increased Flavonifractor may potentially compromise GABA availability, since these bacteria primarily utilize GABA for metabolism (Tanelian et al., 2023) potentially affecting this key inhibitory neurotransmitter and contributing to anxiety symptoms observed in PTSD (Strandwitz et al., 2018)

DOI: 10.1016/j.jpsychires.2013.11.011 64

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In mouse models of oxygen-induced retinopathy (OIR), low-dose IL-2, which has been shown to upregulate surface TFR1 expression, was observed to expand CD4+CD25+Foxp3+ Tregs, thereby effectively attenuating retinal vasculopathy (59, 60)

doi: 10.1021/acssuschemeng.0c06645 143 FusterMGCarissimiGMontalbnMGVlloraG