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The glutathione-dependent pathway yields glutathione conjugate, S -(1,2-dichlorovinyl)glutathione, which occurs predominantly in the liver and can also occur in extrahepatic tissues, but additional biotransformation of S -(1,2-dichlorovinyl)glutathione takes place in the kidney

It summarizes the differences as well as recommends one of the systems depending on the properties of the target protein, expression host, and purification conditions

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JBI Evid Synth 19:695701 Myhill S, Booth NE, McLaren-Howard J (2009) Chronic fatigue syndrome and mitochondrial dysfunction

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