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Pharmacogenomic research shows that genetic changes in drug-metabolizing enzymes, transporters, and targets can affect curcumins pharmacokinetics and pharmacodynamics

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Finally, iNOS itself is inhibited by S-nitrosylation (131, 132), suggesting that NOS uncoupling may be further perpetuated by an increase in iNOS expression under conditions that support superoxide production and BH4 depletion supporting the idea that NOS uncoupling may function as a molecular switch

10.1016/j.watres.2018.10.068 [PubMed: 30408731] [CrossRef] Tovar AP, Navalta JW, Kruskall LJ, Young JC (2017)