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The main barrier is the stratum corneum, which blocks large molecules like peptides

However, injections of melatonin have been shown to inhibit UV-induced cataract in rats, 14 and oral melatonin reduces IOP in normal patients

Interestingly, an increased abundance of Sutterella may be associated with autism spectrum disorder (205)

Moreover, oral administration of supplements containing GR and active myrosinase (2.2 mol SF/kg/day for 14 days) increased mRNA levels of cytoprotective enzymes and heat shock proteins while decreasing mRNA levels of pro-inflammatory markers in peripheral blood mononuclear cells (PBMC) of patients with ASD (41)

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