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23 describes the RNAi potency of siRNA/Ap-CS in A549 cells, demonstrating the developed siRNA delivery vehicles are suitable for the therapeutic intervention of other types of tumor cells, e.g., adenocarcinomic cell line

doi: 10.1177/00220345930720020801 119 PasseyRJWilliamsELichanskaAMWellsCHuSGeczyCLet al

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The expression of BOLA3 is reduced due to HIF-2-dependent transcriptional inhibition, and its deletion disrupts the integrity of iron-sulfur (Fe-S) clusters, affects the function of two-oxoacid dehydrogenases containing lipoic acid, and regulates glycolysis and mitochondrial respiration