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This is one of the effects that is considered beneficial, beside the increase of DS

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In addition, T-cell PTP (TCPTP) dephosphorylates STAT3 and thus attenuates insulin signaling in mouse liver [88]

Diabetes Metab J 39(4):291303 Bashiardes S, Shapiro H, Rozin S, Shibolet O, Elinav E (2016) Non-alcoholic fatty liver and the gut microbiota

Several ongoing clinical trials are investigating antibodies' effectiveness primarily targeting CD39 or CD73, combined with immune checkpoint inhibitors (ICI) or alongside chemotherapy