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doi: 10.1164/rccm.202106-1426OC 110 Jarosz-GriffithsHHScamblerTWongCHLara-ReynaSHolbrookJMartinonFet al

Risk increases substantially with unregulated peptide sourcing, where endotoxin contamination and incorrect reconstitution are documented concerns

Network modeling Graph neural networks and other advanced computational tools now enable simulations wherein perturbation of a single node, for example, HSP90 inhibition, can be computationally modeled to predict downstream shifts in UPS engagement or autophagy induction