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Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

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Huo et al., 2020)

identified necroptosis-related phenotypes in LUAD, developing a NecroScore that stratifies patients based on survival, immune response, and therapy sensitivity (Zhao et al

The optimal dosage varies based on individual health needs, lifestyle factors, and specific goals, but general recommendations suggest a range of 250 mg to 1,000 mg per day