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In meta-analyses, older men and women (even into their 80s) showed significant gains in lean mass and strength after 12+ weeks of high-volume, moderate-to-heavy resistance exercise ( 2 max and walking speed, and sustain oxidative enzyme levels in muscle ( 3.4 Cognitive and brain health Aging brains benefit from physical activity, too

Besides, only PPAR was lower in WT mice than in IL-6 KO mice following exercise intervention, suggesting that IL-6 selectively targets PPAR-dependent lipogenic pathways to prevent excessive lipid deposition in the liver