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Several studies indicate that the Janus kinase 2 (JAK2)-STAT3 pathway is a crucial mechanism mediating IL-1 release from astrocytes

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This was clearly demonstrated by Giri and coworkers (1984), and similar mechanisms might operate in the spontaneous disease as well (Liu et al

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The effect of GH and IGF-1 on linear growth and skeletal development and their modulation by SOCS proteins