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To achieve a power of 80% at = 0.05, we estimated that a minimum of 16 cases and 32 controls would be required

doi: 10.1159/000495037 113 SchroderK.TschoppJ

Until 2008, the International Society of Sexual Medicine (ISSM) proposed a multivariate evidence-based definition of lifelong premature ejaculation: a male sexual dysfunction characterized by ejaculation which always or nearly always occurs prior or within about 1 min of vaginal penetration

Skin reactions: Skin rash and nausea have been reported with oral supplementation [29]

End points The primary end points included the occurrence of solicited AEs during the supplementation period and unsolicited AEs within the 28 days following the start of supplementation