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The sensor is part of a protein that does triple duty: it senses, regulates, and delivers the antioxidant glutathione into the mitochondrial interior, where it plays critical roles in tamping down oxidizing reactions and maintaining appropriate iron levels

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Further, they can decrease the expression of the VEGF, which suppresses angiogenesis, and they can inhibit matrix metalloproteinases (MMP-2, MMP-9) which inhibit the potential for metastasis (167)

Similarly, a Korean cohort of 199,468 adults demonstrated a positive, doseresponse relationship between smoking exposure and both incident MASLD and fibrosis severity