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Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons

doi: 10.1016/j.freeradbiomed.2024.05.040 251 LiuXPanFShaCWangZLiuGWangHet al

Our finding that APOE4 upregulates protein expression in young mice in a pattern that would likely support energy metabolism is consistent with a study from Perkins et al., which demonstrated increased levels of proteins involved in glucose transport and oxidative phosphorylation in the posterior cingulate brain region of young adult APOE4 carriers compared to non-carriers (Perkins et al., 2016)

After cooling, samples were diluted with 15 ml distilled water to give a final nitric acid concentration of 3.5% required for inductively coupled plasma mass spectroscopy analysis