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GW4869, an inhibitor of sphingomyelinase, ameliorated extracellular vesicles (EVs) generated by T lymphocytes and reduced macrophage migration and infiltration, thereby inhibiting the development of AAA in elastase-deficient mice[133]

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DHODH inhibition also promotes significant increases in mitochondrial mass with 72 h treatment that is rescued with uridine supplementation (Fig

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