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Methods Mol Biol 132:365386

Heme degradation and oxidative stress in murine models for hemoglobinopathies: Thalassemia, sickle cell disease and hemoglobin C disease

Even though it was believed that most of the immune cells and other soluble molecules cannot pass between the CNS and other organs because of BBB and it protects the CNS from inflammation caused due to pathogens access to the host, it is known that the CNS has to be regularly checked for its proper functioning to ensure the absence of any injury or damage because of some pathogen [34, 58]