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This increase in oxidative response in turn has been related to the periodontal condition of the patients.8,24 Based on our results, it may be concluded that poorer metabolic control in patients with T2DM leads to greater levels of salivary oxidative stress, which in turn results in poorer periodontal health

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depending on the distance from the tumor site, TRMs tend to increase in number with proximity, and TRMs can promote or inhibit the progression of different tumor types, exhibiting spatial heterogeneity (242)

, proto- or mesoheme) bound to HPX affects neither HPX endocytosis nor heme-dependent HMOX1 induction (see Figure 7)