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Substantial evidence indicates that mutations in several PD-associated genes (e.g., LRRK2, GBA, PINK1, PRKN, *DJ-1*) and the expression of risk alleles such as APOE4 exert their pathological effects by disrupting autophagy-related pathways, notably the autophagy-lysosomal pathway and mitophagy (3)

doi:10.1371/journal.pgen.1002947

558 Therefore, they designed a randomized crossover experiment involving 32 healthy adults taking 100160 mg Mito-Q or placebo, and after 46 h urine results showed no significant differences between these two groups

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Nature 417 , 447452 (2002)