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Here, the aminopeptidase trims cross-presented peptides in a specific endosomal compartment, described in dendritic cells, [15] before their loading on IRAP-associated MHC class I molecules

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Suspend an IV bag above the patient to utilize gravity for steady infusion

Heme oxygenase 1 (HO-1) is an NRF2 target gene that prevents FH deficiency-mediated succinate stagnation through the heme synthesis and degradation pathway ( BEYOND REGULATING REDOX HOMEOSTASIS: NRF2 PROMOTES ANABOLIC PATHWAYS IN CANCERS In addition to coordinately activating the genes encoding detoxifying enzymes and antioxidant proteins, the constitutive accumulation of Nrf2 confers chemo- and radio-resistance for cancer cell survival