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It is also contraindicated in patients with certain kidney disorders where high-dose vitamin C is not advisable

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Citation43 In a study by Sang et al using in vitro experiments with LPS-stimulated ML-12 cells, Quercetin was found to modulate the SIRT1/AMPK pathway to inhibit both endoplasmic reticulum stress and oxidative stress levels in cells, which was manifested by a decrease in the expression of PDI, CHOP, GPC78, ATF6, PERK, and IRE1A, together with enhanced mitochondrial function, and increased levels of matrix metalloproteinase (MMP) and superoxide dismutase (SOD) while reducing the production of ROS and MDA, which in turn reduced the release of inflammatory factors in the cells

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