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Homeodomain interacting protein kinase 2 (HIPK2) negatively regulates the expression of NMDAR subunit GluN2A and GluN2C and knockout of Hipk2 in the mouse brain increases the expression of GluN2A and thus the GluN2A/GluN2B ratio through altering JNK (c-Jun N-terminal kinase)-c-Jun signaling pathway [139]

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