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Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model

This indicates that while higher doses may have some impact on kidney function, this effect is reversible and does not occur at lower, more commonly used doses

Haugstvedt JR, Berger RA, Nakamura T, Neale P, Berglund L, An KN

In some embodiments, the otic formulation or composition comprises about 9% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Investigators also collected serial blood samples to track shifts in lipids, C-reactive protein, and liver enzymes, providing a broader picture of metabolic health