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Schmitz and colleagues [76] demonstrated that the IP3R is co-activated by IP3 and calcium ions and is potentiated by ATP

Mutations in KEAP1 or the augmentation of SQSTM1 (sequestosome 1)-mediated KEAP1 protein degradation can enhance the stability of NFE2L2 protein, enabling cancer cells to evade ferroptosis and acquire drug resistance [34]