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PDK1 inactivates the pyruvate dehydrogenase (PDH) complex through inhibitory serine phosphorylation of the pyruvate dehydrogenase E1 alpha subunit (PDHA1), preventing pyruvate from being converted to acetyl Co-A, thus hindering the initiation of the TCA cycle 1 , 6 , 7

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Mistake 1: confusing concentration after reconstitution This is the most common and most dangerous error

First report of total gastrectomy for asymptomatic CDH1 germline carriers van der Post RS, Vogelaar IP, Carneiro F, et al