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4a, although the fluorescent ApoE-PDHD accumulated quickly alongside the wall of brain microvessels due to the binding function of ApoE, the fluorescence outside the cerebral vessels of mice injected with ApoE-free BEAGA-PDHD or ApoE-PDHD was hardly detected throughout the whole experiment time, suggesting that the ApoE decoration alone facilitated a low BBB-crossing efficiency 33

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