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Eskes hypothesized that hyperhomocysteinemia, even with normal folate levels, could be a toxic agent for the developing embryo ( Current issues and controversies Excess folic acid exposure and exacerbation of vitamin B12 deficiency Homocysteine lies at the intersection of folate and vitamin B12 metabolism, and the biological and clinical interaction between these two vitamins has been a subject of considerable interest for decades

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[DOI] [PMC free article] [PubMed] [Google Scholar] 243.Crispo M., Mulet A., Tesson L., Barrera N., Cuadro F., dos Santos-Neto P., Nguyen T., Crnguy A., Brusselle L., Anegn I

doi: 10.1016/0140-6736(93)90882-h