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To help manage potential side effects, doctors generally prescribe a starting dosage of 2.5 mg weekly and gradually increase to higher doses every 4 weeks while your body gets used to the medication until an effective maintenance dosage is reached

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peripherally (i.e., portal, superior mesenteric, lienal and inferior caval vein)) and arterial (i.e., abdominal aorta thrombosis, thus low-flow state caused by cardiac dysfunction or sever volume depletion [68])

Consistent with this observation, Fountoulakis et al

This pathway is activated when cells experience stress related to the accumulation of unfolded proteins in the ER