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Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation

nonetheless, certain DNA lesions can escape repair or exceed the repair capacity and eventually accumulate in the genome

In this sense, it has been reported that binding of mutp53 to particular motifs on non-B DNA conformations, confers stability to mutp53, but also makes it more selective for modifying the activity of both transcription factors and chromatin remodelers (Ghler et al., 2005