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Modern DDSsincluding lipid-based, polymeric, and stimuli-responsive platformshave demonstrated superiority over conventional therapies by optimizing pharmacokinetics, minimizing off-target effects, and enabling targeted delivery to pathological sites (e.g., renal tubules and inflamed joints)

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Simultaneously, FXR activation restores the intestinal vascular barrier by triggering the endothelial Wnt/-catenin pathway, which blocks bacterial translocation and alleviates hepatic inflammation (Mouries et al., 2019)

For example, MR parameters such as voxel size (measurement of the image resolution or detail) and MR image acquisition time (e.g., up to 8 seconds) may contribute to inaccurate MR thermometry readings and potential errors in the ablation assessment