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Description

[] Liver injury is a global health issue that poses a serious threat to human health

Future opportunities include hybrid nanoplatforms that integrate redox responsiveness with imaging and enhanced safety, as well as the use of patient-specific GSH/GSSG profiles to guide individualized therapy

Romashkan S, Chang H, Hadley EC

J Biol Chem 268 : 1788317888

These shifts are compounded by impaired antioxidant defenses, including downregulation of GPX4 and system Xc - which diminish glutathione synthesis and the capacity to neutralize lipid hydroperoxides