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Key points Non-myeloid kidney parenchymal cells (KPCs) express molecules that are shared with immune cells

It was first isolated in human plasma in 1973, and subsequent decades of research have revealed a mechanism that goes considerably beyond simple collagen stimulation

Furthermore, pro-inflammatory microglia have been reported to promote distant inhibition of ferroptosis (83, 151), indicating that these cells possess the anti-ferroptosis properties in neuroinflammation

All experiments were approved by the Institutional Animal Care and Use Committee at the Albert Einstein College of Medicine (Protocol #20140107)

The niche where IGF-1 LR3 consistently outperforms: acute recovery from injury or training overreach