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Description

In fact, the NAD + glycohydrolase activity of CD38 was essential for tumor progression by downregulating tumor suppressors (such as KEAP1) and upregulating oncogenes (such as NRF2) [46]

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Strong CYP3A inhibitors (such as ketoconazole, itraconazole, and ritonavir) would be expected to increase orforglipron exposure, potentially necessitating dose adjustment

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