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As emphasized by Zhao et al., the prolonged progression of AD before clinical symptoms emerge indicates that astrocytes may substantially contribute to disease pathogenesis at a single-cell resolution 12

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On the other hand, brown adipose tissue (BAT) is specifically saturated with mitochondria rich in iron, giving BAT its unique color and is highly concentrated in GSSG rather than GSH

Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author

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