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It is located at about 3,650 meters above sea level in the southwest of Bolivia, in the Daniel Campos province, in the department of Potos, within the highland region of the Andes Mountain

Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear