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It reaches these cardiac receptors too

And stopping them

A recent study has demonstrated that an acute increase in the intracellular concentration of ROS inhibits the glycolytic enzyme pyruvate kinase M2 (PKM2) through the oxidation of Cys358 (Anastasiou et al., 2011)

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Effect on cell viability was assessed 72 h after transfection with GSTO1 siRNA or siSCRAM by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and normalized to mock-transfected control (transfection reagent)