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The animal experiment used 24 female Sprague Dawley rats weighing 100140 g and randomized them into four groups with following treatments: normal control, bilateral oophorectomy, 17--estradiol (10 g/kg body weight) and cynaroside (5 mg/kg body weight)

Ponte G, Roumbedakis K, Galligioni V et al (2023) General and species-specific recommendations for minimal requirements for the use of cephalopods in scientific research

In addition, the synergy may be strong or moderate when the means of FIC index values are respectively below 0.5 or between 0.5 and 1

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doi:10.3389/fnut.2018.00087 [PubMed] Zhang H, Tsao R