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There are three isoforms of NOS: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) [50]

While iron and transferrin have been shown to induce hepatic stellate cell activation and collagen expression in vitro [86,87,88], in vivo models of iron overload demonstrate only minor fibrosis, although the numbers of alpha-smooth muscle actin (SMA)-positive myofibroblasts were significantly increased [89, 90]

Catalase and glutathione peroxidase ( GPx1 ), the subject of this trait, are other antioxidant enzymes

Recent clinical studies using 1 H-MRS showed that GSH levels in the brains of ALS patients were decreased compared to those of age-matched healthy volunteers [111], and the decreased GSH levels in the motor cortex and corticospinal tract were inversely correlated with the time after diagnosis [112]

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