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2.3 Key bile acid-sensing receptors modulating the TIME 2.3.1 Farnesoid X receptor: transcriptional control linking metabolism and immunity in the TIME The farnesoid X receptor (FXR, encoded by NR1H4), a nuclear receptor superfamily member, is highly expressed in enterohepatic tissues and various immune cells (e.g., macrophages, DCs, T cells) ( Functionally, FXR-mediated transcription often promotes anti-inflammatory effects and supports immune homeostasis

doi: 10.1016/S0306-4522(96)00600-8 55 SoubannierV.McLellandG

501 Activation of Nrf2 prevents ferroptosis by upregulating ferritin, SLC7A11 and GPX4

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