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This remained true on multivariable analyses (see Table)

doi: 10.1111/andr.13175

To overcome these limitations, a number of pharmacological approaches have been developed over the past decades, but these drugs are generally of fairly limited efficacy, expensive and can in some cases cause significant side effects

This cascade reaction initiated by the DAMPs-DC axis not only strengthens the synergistic effects of innate and adaptive immunity but also provides a theoretical framework for DC-targeted vaccine design or combined immune checkpoint blockade therapy (209)