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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis

Overexpression of MAPKAPK2 effectively alleviated key pathological features, including ROS accumulation, impaired melanogenesis, and increased apoptosis, potentially via KEAP1/Nrf2/HO-1 signaling activation