chac1 glutathione L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated degradation in hepatocellular carcinoma Mammalian proapoptotic factor ChaC1 and
Mammalian proapoptotic factor ChaC1 and its homologues function as glutamyl cyclotransferases acting specifically on glutathione EMBO Reports Springer Nature Link TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione degrading enzyme CHAC1 ScienceDirect Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC Nature Communications Glutathione (GSH) depletion by ChaC1 results in a more oxidizing Download Scientific Diagram Frontiers The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications
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