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Although this study revealed that the inhibition of mGluR5 in normoxia did not induce any change, another study found that the Riluzole treatment in normal conditions inhibited proliferation, induced apoptosis, and prevented migration of human osteosarcoma LM7 cells (76)

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Ultimately, for the CSCs to maintain GIN and play a role in the carcinogenic characteristics, they transform the GINs

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