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Description

Trypsin-digested WT samples (control and inactivated ones) subjected to Q-TOF MS showed several peptide ions (details about peptide fingerprinting are shown in Additional file 1: Figure S1a, b)

Composed of the light chain subunit solute carrier family 7 member 11 (SLC7A11) and the heavy chain subunit SLC3A2, System Xc imports extracellular cystine, which is then rapidly reduced to cysteine intracellularly (28)