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10.1016/j.mito.2009.11.001 Mitochondrion 287 LongeckerM

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The involvement of mitochondria in ferroptosis as an important source of ROS is still the current mainstream view, since mitochondrial ROS (mitoROS) is mainly produced by oxidative phosphorylation (OXPHOS) complexes in mitochondria ( Although mitochondria are closely related to ROS production and iron metabolism, the causal relationship between morphological changes of mitochondria and ferroptosis remains unclear