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Of note, besides p53 the ability of APR-246 to induce cell death has also been ascribed to the inhibition of TXNRD1 [57, 58]

E.SalasekM

Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury

JAMA (2017) 318:198593

By removing interactions we can take the model apart piece by piece so that we can understand how and why glutathione metabolism works the way it does