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An impossible dream

*Correspondence: Xiaohong Sui [email protected] Wang [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

DET1 serves as a structural scaffold, bridging COP1 and Ube2e2 to initiate potential ubiquitin addition on substrates, while DDB1 recruits the CULLIN4-RBX1 complex to facilitate Ube2d3-mediated ubiquitin chain elongation

Glutathione helps reduce oxidative damage to skin cells and has been shown to influence melanin production, which contributes to a more even skin tone

The histologic hallmark is the Schiller-Duval body, which resembles a primitive glomerulus