Err on the side of caution and discontinue use when planning pregnancy or while nursing
Key Points The anorexigenic hormone leptin and the orexigenic hormone ghrelin are crucial for metabolic regulation and energy homeostasis Obesity-associated resistance to leptin and ghrelin promotes adiposity and might contribute to the diseases that are associated with this condition beyond metabolic disorders Resistance to leptin and ghrelin is a multifactorial process that involves changes at several levels: from disturbed hormonal production to altered receptor trafficking and signalling in the brain Several molecules and signalling pathways associated with leptin and ghrelin receptors have been identified as potential targets to overcome resistance to these hormones, but none has reversed the energy imbalance in the long term The identification of novel molecular targets and pathways that can be modulated to enhance sensitivity to leptin and ghrelin and restore energy homeostasis is necessary for the development of efficient pharmacological treatments for obesity Abstract Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases and certain types of cancer, arises from a chronic positive energy balance that is often due to unlimited access to food and an increasingly sedentary lifestyle on the background of a genetic and epigenetic vulnerability
Fibulins: multiple roles in matrix structures and tissue functions
Despite its incorporation into clinical trials, the application of anti-CD25 mAb faces challenges, primarily because CD25 is expressed not only on Tregs but also on effector T cells 17,19
Researchers continue to investigate the biological pathways responsible for extracellular matrix maintenance and remodelling, as these processes play a fundamental role in normal physiology
