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Similar content being viewed by others Introduction Pegylated uricases, such as pegloticase and pegadricase, are enzyme therapies that rapidly metabolize uric acid and are promising therapies for the treatment of chronic gout in adult patients that are refractory to conventional therapy 1,2,3,4,5

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By forming transient nanopores on epithelial cell surfaces, these enhancers have enabled sublingual absorption of proteins up to 150 kDa in animal models, with effects comparable to subcutaneous injection