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It is estimated that approximately 70% of patients receiving chemotherapy develop CIPN during the first month of treatment [17, 20], whereas in approximately 2030% of these patients, CIPN might be converted to a chronic, persistent and highly pharmacoresistant form [17, 23] that can be observed 6 months or even longer after therapy cessation [14, 16, 27, 28]

1,2 However, the literature is lacking with respect to defining the clinical needs of patients affected by the Rett Syndrome and there is no review available on the current therapeutic options

Given the vitamins water-soluble nature, excess vitamin C is excreted in the urine without complications